用多智能体系统自动整合神经数据,加速发现脑机制。
SeekBrain: An Autonomous Multi-Agent System for Accelerating Neuroscience Discovery

- 构建代码论文对生成分析方案库,实现领域知识编码
- 在BrainArena上表现优于现有基线模型,任务完成率显著提升
- 适合神经科学家快速探索跨模态数据,尤其擅长行为与脑区关联分析
现代神经科学依赖多尺度、多模态数据整合以揭示智能的神经机制。然而,异构数据与碎片化工作流带来了分析挑战。本文提出SeekBrain,一种基于领域知识的分层规划与跨模态分析的自主多智能体框架。该系统通过代码-论文对动态构建分析配方库,结合代理式规划与执行引擎,可按需生成假设与分析流程。在专家标注的BrainArena基准上系统评估显示,SeekBrain在各类分析任务中显著优于当前最优代理基线。关键的是,在真实研究中,它整合了行为、神经与解剖数据,揭示了幼年斑马鱼行为的结构化分布式神经表征,以及小鼠决策任务中全脑区域解码强度共享轴。这些结果确立了SeekBrain作为可扩展、实用的数据驱动神经科学发现工具。
原文摘要 · Abstract (English)
Modern neuroscience relies on integrating multi-scale, multimodal datasets to uncover the neural principles underlying intelligence. However, analytical challenges posed by highly heterogeneous data and fragmented workflows increasingly constrain discoveries. Here we introduce SeekBrain, an autonomous multi-agent framework designed to accelerate neuroscience discovery through domain-grounded hierarchical planning and cross-modal data analysis. SeekBrain dynamically constructs a repertoire of analysis recipes extracted from code-paper pairs. By coupling this codified expertise with agentic planning and execution engines, the framework scalably generates hypotheses and analytical pipelines on demand. Systematic evaluation on the expert-annotated BrainArena benchmark demonstrates that SeekBrain substantially outperforms state-of-the-art agent baselines across various analysis tasks. Crucially, when deployed in real-world research, SeekBrain integrated behavioral, neural, and anatomical data to reveal structured, distributed neural representations of larval zebrafish behavior and a shared axis of regional decoding strength across the brain in a mouse decision-making task. These results establish SeekBrain as a scalable and practical tool for accelerating data-driven discoveries in neuroscience.
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