通过动态融合多期医学影像特征,提升病灶分割精度与鲁棒性。
DynoDINO: Harnessing Dynamic Latent Information from DINO Features for Multi-Phase Medical Image Segmentation

- 基于多阶段特征校准与自适应门控机制,动态整合时间信息。
- 在三个数据集上实现边界更清晰、结构更保真的分割效果。
- 适合需要处理不完整或错位多期影像的临床分割场景。
多期增强计算机断层扫描(CECT)通过捕捉不同时间点的对比剂强化模式,在病灶诊断与特征分析中起关键作用。然而,由于临床相关的对比剂动力学分布于各期之间,加之解剖不一致、呼吸运动及采集不全导致的相间错位和时序信息中断,准确分割仍具挑战。传统方法通常独立处理每期或采用简单融合策略,难以充分建模时间关系。为此,我们提出DynoDINO,一种统一框架,首先进行切片级对齐建立相间解剖对应关系,再通过多期融合模型联合增强跨期相关性。该模型引入混和注意力机制实现高效多期特征校准,并设计基于差值残差学习的自适应门控机制,选择性保留诊断相关对比变化,抑制残余错位带来的伪影。该机制还通过避免无指导减法操作,提升训练稳定性。在LiTS、PLC-CECT与WAW-TACE三个大规模数据集上的实验表明,DynoDINO在标准、偏移及缺失相条件下的边界划分与结构保真度均持续提升。
原文摘要 · Abstract (English)
Multi-phase Contrast-Enhanced Computed Tomography (CECT) plays a central role in the diagnosis and characterization of focal lesions by capturing temporal enhancement patterns across multiple acquisition phases. Accurate lesion segmentation from such data remains challenging because clinically relevant contrast kinetics are distributed across phases, while anatomical inconsistencies, respiratory motion, and incomplete acquisitions often lead to inter-phase misalignment and interrupted temporal information. Conventional segmentation frameworks typically process each phase independently or rely on simple fusion strategies, limiting their temporal reasoning capability. To address these challenges, we propose DynoDINO, a unified framework tailored to address the core challenges of multi-phase medical image segmentation. DynoDINO first performs slice-level alignment to establish inter-phase anatomical correspondence and then employs a Multi-phase Fusion Model to jointly enhance temporal correlations across phases. Our fusion model incorporates a Mix-attention (MA) mechanism for efficient multi-phase feature calibration and an Adaptive Gating Mechanism with difference-based residual learning to selectively preserve diagnostically relevant contrast variations while suppressing artifacts caused by residual misalignment. In addition, the adaptive gating mechanism improves training stability by preventing feature degradation caused by unguided subtraction operations. Experiments on three large-scale datasets, including LiTS, PLC-CECT, and WAW-TACE, demonstrate that DynoDINO consistently improves boundary delineation and structural fidelity under standard, shifted, and missing-phase conditions.
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