用手持探头多点测量，提升口腔癌手术中肿瘤边界定位精度

Objective: Positive margins in oral squamous cell carcinoma (OSCC) resection are common and significantly impact patient outcomes. Electrical impedance tomography (EIT) can be used to intraoperatively distinguish cancer from healthy tissue. The objective of this study was to develop and identify a fused EIT approach to accurately reconstruct a tumor boundary using multiple impedance measurements recorded with a handheld electrical impedance probe. Approach: Simulations and noise analyses were used to investigate the best reconstruction method for fused EIT, and a measured phantom experiment was conducted to evaluate the EIT reconstructions. Main results: Fused approaches successfully and accurately recovered the conductivity boundary location from multiple probe sites, increasing boundary localization to within 0.5 mm of the true boundary for both simulated and experimental results. Simulations and noise analysis revealed that all reconstruction methods maintain strong classification accuracy with added noise on a half-plane boundary scenario and fused difference EIT is the most robust to all types of added noise, due to the high data redundancy in the reconstruction formulation. Significance: The measured multi-site probe experiments represent important steps in the development of an approach that can combine EIT from multiple locations to increase boundary localization accuracy. Overall, this result is a step towards a clinically deployable impedance imaging approach to scanning the entire tumor boundary, which could significantly help to improve surgical outcomes for OSCC.