用配对受者法评估肾移植生存预测模型,发现准确率达60%。
Paired Recipient-based Evaluation of Survival Prediction for Deceased Donor Kidney Transplants
- 通过同一捐献者供肾给两名受者的对比,评估预测模型效果。
- 五种模型在配对受者中均达到约60%的预测准确率。
- 新指标更贴近临床实际,优于传统C指数评价方式。
近年来,机器学习被用于预测肾移植后移植物失败时间,以优化捐献者与受者匹配。本研究基于科学移植受者登记数据库(SRTR)数据,提出一种新型配对受者评估框架,比较同一捐献者供肾给两位受者时的移植物结局,从而评估更换受者的潜在获益。结果表明,五种不同复杂度的生存预测模型(从线性到深度学习)在该框架下均实现约60%的配对受者准确率。进一步将此准确率转化为术后可获得的生存年数。研究还指出,传统一致性指数(C-index)在该场景中存在局限,而提出的配对受者准确率更具临床相关性,更符合真实分配情境。
原文摘要 · Abstract (English)
There has been significant interest in using machine learning algorithms to predict kidney transplant outcomes, such as the number of years until a graft inevitably fails. These prediction algorithms could possibly be used for pre-transplant donor-recipient matching to identify more compatible donors and recipients and thus improve post-transplant outcomes. In this study, we explore the use of survival prediction models trained on deceased donor kidney transplant data from the Scientific Registry of Transplant Recipients (SRTR). We propose a novel paired recipient-based evaluation framework that compares graft outcomes between two recipients who received kidneys from the same deceased donor, allowing us to evaluate the counterfactual benefit of changing the recipient for a certain donor. We find that five different survival prediction models, ranging in complexity from linear to deep learning-based models, all result in ~60% paired recipient-based accuracy. We further translate this accuracy into an interpretable quantity of post-transplant years gained. We also highlight major limitations of the commonly used concordance index (C-index) metric for evaluating survival prediction accuracy in this setting and demonstrate that our proposed paired recipient-based accuracy metric is more clinically relevant and better reflects real-world allocation settings.
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