arXiv:2608.03664cs.CV2026-08

提出Morph-ISR模型,精准恢复病理图像细胞结构细节。

Morphology-Aware Implicit Super-Resolution Network for Pathological Images

论文配图:Morphology-Aware Implicit Super-Resolution Network for Pathological Images
图 1 · 摘自论文原文
  • 将超分辨重构为坐标连续建模,引入位置感知核生成器
  • 在TCGA和SurGen数据集上降低LPIPS达38.37%,保持边界清晰
  • 适合需要高精度病理分析的临床部署场景

数字病理依赖高分辨率全切片图像进行准确诊断,但临床部署常受硬件成本限制。超分辨率(SR)通过计算增强低分辨率图像提供替代方案,但现有方法常难以保留细粒度细胞形态,导致纹理过度平滑和结构边界模糊。为此,我们提出Morph-ISR,一种面向数字病理的形态感知隐式超分辨框架,以亚像素精度恢复诊断相关细节。Morph-ISR将超分辨重建成连续坐标基重构问题,并引入隐式位置感知核生成器(IPKG),自适应建模空间变化的组织形态。为进一步提升结构保真度,设计了形态保真先验(MFP),利用预训练细胞分割网络的语义引导,强制边界保持与区域感知重建,显著改善关键细胞边界与核纹理表示。在TCGA与SurGen数据集上的实验表明,Morph-ISR在评估指标中表现最优,相比次优方法,LPIPS与ST-LPIPS分别降低38.37%与39.55%,同时保持良好PSNR与SSIM。结果证明其在细胞边界与核纹理上的优越保真能力,且参数紧凑、吞吐率高,支持高效边缘部署。代码与训练模型将在发表后公开。

原文摘要 · Abstract (English)

Accurate diagnosis in Digital Pathology (DP) relies on high-resolution whole-slide images, yet clinical deployment is often limited by hardware costs. Super-Resolution (SR) offers a promising alternative by computationally enhancing low-resolution acquisitions. However, existing SR methods frequently struggle to preserve fine-grained cellular morphology, leading to texture oversmoothing and blurred structural boundaries under complex tissue variability. To address this issue, we propose Morph-ISR, a morphology-aware implicit super-resolution framework for DP that restores diagnostically relevant details with sub-pixel precision. Morph-ISR reformulates SR as a continuous coordinate-based reconstruction problem and integrates an Implicit Position-aware Kernel Generator (IPKG) to adaptively model spatially varying tissue morphology. To further enhance structural fidelity, a Morphological Fidelity Prior (MFP) is introduced, leveraging semantic guidance from a pre-trained cell segmentation network to enforce boundary-preserving and region-aware reconstruction, thereby improving the representation of critical cellular boundaries and nuclear textures. Experiments on TCGA and SurGen datasets show that Morph-ISR achieves the best LPIPS and ST-LPIPS among the evaluated methods, reducing them by up to 38.37% and 39.55%, respectively, over the second-best methods while maintaining strong PSNR and SSIM. These results demonstrate superior preservation of diagnostically relevant cellular boundaries and nuclear textures, while compact parameterization and high throughput support efficient edge deployment. Code and trained models will be released upon publication.

超分辨率病理图像形态感知隐式网络

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