用无监督对抗域适应,把动态核磁图像的子宫分层精度提升到0.88
Unsupervised Adversarial Domain Adaptation for Uterine layer Segmentation: From Labeled Cine to Unlabeled Dynamic EPI MRI

- 设计了带时序特征的无监督对抗域适配框架,从标注的电影磁共振迁移知识到未标注的动态EPI
- Dice分数达0.88,Jaccard指数0.80,首次发现14例中肌层交界区面积与T2*呈负相关
- 适合关注子宫动力学与组织氧合关系的研究者,尤其对妇科疾病机制探索有启发
子宫蠕动是月经周期中多项生理功能的关键,与子宫壁微观结构密切相关。子宫运动及组织性质的改变与妇科疾病病因相关,但两者常被孤立研究。我们提出一种动态多回波梯度回波EPI方法,在0.55T下同步表征子宫蠕动活动与时间分辨T2*变化。针对固有敏感性伪影、分辨率低及人工标注耗时问题,引入无监督对抗域适配框架,将标注的电影MRI分割知识迁移至未标注的动态EPI数据。采用Unet-LSTM结合多尺度域判别器,利用时序层动态特性。达到Dice分数0.88,Jaccard指数0.80。各层平均T2*值分别为:肌层108ms,交界区76ms,内膜124ms。在39例中有14例观察到交界区面积与T2*呈负相关,首次揭示其与交界区收缩及运动相关的氧合模式,证明评估收缩力与动态T2*变化相互作用的可行性。
原文摘要 · Abstract (English)
Uterine peristalsis is a key physiological phenomenon responsible for various functions across the menstrual cycle, intimately linked to uterine wall microstructure. Alterations in uterine motion and tissue properties are implicated in the etiology of gynecological diseases, yet these processes have been studied in isolation. We introduce a dynamic multi-echo gradient echo EPI framework for simultaneous characterization and correlation of uterine peristaltic activity and time-resolved T2* changes at 0.55T. Inherent susceptibility artifacts, reduced resolution, and burden of manual uterine layer annotation are addressed by an unsupervised adversarial domain adaptation framework, transferring segmentation knowledge from labeled cine MRI to unlabeled dynamic EPI. We implemented Unet-LSTM with multi-scale domain discriminators that exploits temporal layer dynamics. A Dice score of 0.88 and Jaccard index of 0.80 was achieved. Mean T2* values were 108ms, 76ms, and 124ms for the myometrium, junctional zone, and endometrium. A negative correlation between junctional zone area and T2* was observed in 14/39 cases, providing first insights into oxygenation patterns associated with junctional zone contraction and motion, demonstrating feasibility of assessing the interplay between contractility and dynamic T2* changes.
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