tSCS干扰脚踝本体感觉，使步态更受限，但训练可促适应改善。
Transcutaneous Spinal Cord Stimulation Disrupts Conscious Ankle Proprioception and Produces a More Constrained Locomotor Pattern in Unimpaired Adults
- 通过刺激脊髓影响本体感觉与步态控制通路。
- 急性刺激后本体感觉误差显著增加，步宽和重心偏移减小（p<0.05）。
- 持续训练可恢复部分步态功能，适合神经康复研究者参考。
经皮脊髓刺激（tSCS）主要通过激活传入网络调节脊髓感觉运动回路。本研究考察了tSCS对14名健康成年人踝关节本体感觉及步态的急性与训练相关影响，另设14人对照组仅接受本体感觉训练无刺激。使用双侧机器人动态踝定位测试（Crisscross）评估本体感觉，最大背屈肌力衡量粗大运动输出，正常与 tandem 跑台行走时采用时空参数、躯干摆动及内外侧重心（CoM）位移测量步态。急性tSCS显著增加踝本体感觉误差（p < 0.001），但背屈力量不变（p = 0.30）。步态呈现轻微更受限模式，表现为步宽和外侧CoM位移减小（p < 0.05）。持续刺激下训练使本体感觉误差下降，且该组在停用刺激后仍保持进步；矢状面步态指标恢复至或超过基线水平，而冠状面指标持续受限，表明运动控制存在方向特异性重构。结果表明，tSCS可同时干扰意识性本体感觉并重塑步态行为，神经系统可通过训练适应异常传入输入。
原文摘要 · Abstract (English)
Transcutaneous spinal cord stimulation (tSCS) modulates spinal sensorimotor circuits primarily through activation of afferent networks. While prior work has emphasized locomotor performance and spinal excitability, how tSCS affects conscious proprioceptive perception and the extent to which such effects parallel changes in locomotor control remain unclear. We investigated the acute and training-related effects of tSCS on ankle proprioception and gait in unimpaired adults (n = 14), with an independent control group (n = 14) completing identical proprioceptive training without stimulation. Proprioception was quantified using a bilateral robotic assessment of dynamic ankle localization ability (Crisscross), gross motor output using maximum dorsiflexion strength, and gait during normal and tandem treadmill walking using spatiotemporal, trunk-sway, and mediolateral center-of-mass (CoM) excursion measures. Acute tSCS increased ankle proprioceptive error (p < 0.001) while dorsiflexion strength was unchanged (p = 0.30). Gait shifted toward a modestly more constrained locomotor pattern, characterized by reduced step width and ML CoM excursion (p < 0.05). With continued training under stimulation, proprioceptive error decreased and, unlike the control group, the tSCS group showed progressive improvement that persisted after stimulation ended. Sagittal-plane gait measures recovered toward or beyond baseline, whereas mediolateral measures remained constrained, revealing a direction-dependent reorganization of locomotor control. Together, these findings show that tSCS influences multiple aspects of the sensorimotor control loop, disrupting conscious proprioception while reshaping locomotor behavior, and that the nervous system can adapt to altered afferent input through training.
Thank you to arXiv for use of its open access interoperability. PaperDance 不是 arXiv 官方产品；中文卡片由大模型生成，请以原文为准。