用原型学习逐步修正偏移,提升医学标志点定位精度。
Rethinking Medical Landmark Localization with Prototype Learning-based Progressive Offset Correction

- 基于原型学习的渐进式偏移修正,分阶段优化标志点位置。
- 在多模态数据上实现高精度定位,误差显著低于现有方法。
- 适合临床影像分析与轻量化模型部署场景。
医学图像中的精准标志点定位是定量临床测量和下游分析的基础。现有方法虽已进步,但多阶段精修策略计算开销大,限制实际应用。本文提出参数高效的PPOC-LL模型,利用原型学习驱动的渐进式偏移修正实现标志点定位。首先,设计多尺度动态感知策略,构建局部特征金字塔;其次,提出相似性驱动的原型学习机制,捕捉关键局部语义以增强偏移预测鲁棒性;最后,引入基于容差平衡的误差感知可靠性正则化,稳定训练过程并提升整体性能。我们在涵盖X光与超声的两组公开及一组私有数据集上验证,覆盖头影测量、耻骨-胎头及胎儿心脏等标志点。大量实验表明,PPOC-LL在准确率与模型复杂度间取得良好平衡。
原文摘要 · Abstract (English)
Accurate landmark localization in medical images is a fundamental step for quantitative clinical measurement and downstream analysis. Existing localization methods have advanced, among which multi-stage refinement is a superior solution. Although this strategy mitigates the anatomical ambiguity inherent in single-stage global predictions, its high computational cost limits practical applicability. In this work, we propose a parameter-economic model, PPOC-LL, which leverages Prototype learning-based Progressive Offset Correction for Landmark Localization. Our contribution is three-fold. First, to drive coarse-to-fine landmark optimization, we introduce a multi-scale dynamic perception strategy for patch-level feature pyramid modeling. Second, to effectively handle anatomically similar patterns, we design a similarity-driven prototype learning mechanism that captures informative local semantics for robust offset prediction. Last, to stabilize the model learning and improve the overall performance, we incorporate a novel error-aware reliability regularization via tolerance-based balancing. We collected a large validation cohort, including two public and one private datasets spanning X-ray and ultrasound modalities, covering cephalometric, symphysis-fetal head, and fetal heart landmarks. Extensive experiments demonstrate that PPOC-LL achieves satisfactory performance with a favorable trade-off between accuracy and model complexity.
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