用眼底照片同时估测儿童近视关键指标,精度超现有方法。
SpecF2M: A Spectral-Aware Multi-task Network Estimating Axial Length and Refractive Error from Pediatric Fundus Photographs

- 设计谱感知多任务网络,融合解剖引导增强与混合空间-谱块
- 在4359名儿童数据上,轴长和屈光度误差分别低至0.53毫米和0.71屈光度
- 发现柱镜与眼底变化关联弱于轴长和球镜,提示不同指标需差异化建模
球面等效屈光度(SER)和轴向长度(AL)是儿童近视筛查的核心指标,但其测量需专用生物测量仪和散瞳验光。眼底摄影提供了一种可及的成像方式,因为近视相关的后极部改变可在45°眼底图像中可见。然而,这些征象通常对比度低、空间弥散且多尺度。此外,AL、球镜(SPH)和柱镜(CYL)具有部分重叠但不完全相同的解剖基础。本文提出SpecF2M,一种基于谱感知的多任务网络,用于从儿童眼底照片中估计AL和SER成分。SpecF2M集成确定性解剖引导增强模块、结合MixCNN与混合谱学习(HSL)块的混合空间-谱骨干网络,以及专家路由头以实现对AL、SPH和CYL的分量级估计。在包含4,359名儿童就诊记录和6,966张眼底图像的儿科队列上,SpecF2M在AL和SPH估计上优于受控的CNN/ViT基线,平均绝对误差(MAE)分别为0.5347毫米和0.7062屈光度。分量级分析进一步揭示任务间不对称耦合现象:与AL/SPH相比,CYL与眼底衍生的近视模式关联更弱。这些结果支持基于眼底图像的近视指标筛查导向估计,但外部验证仍需开展方可部署。
原文摘要 · Abstract (English)
Spherical Equivalent Refraction (SER) and Axial Length (AL) are core indicators for pediatric myopia screening, yet their measurements require dedicated biometry and cycloplegic refraction. Fundus photography offers an accessible imaging modality, as myopia-related posterior-pole changes are visible in 45$^\circ$ fundus images. However, these cues are often low-contrast, spatially diffuse, and multi-scale. Moreover, AL, Sphere (SPH), and Cylinder (CYL) share partially overlapping but non-identical anatomical correlates. We propose SpecF2M, a spectral-aware multi-task network for estimating AL and SER components from pediatric fundus photographs. SpecF2M integrates a deterministic anatomy-guided enhancement module, a hybrid spatial--spectral backbone combining MixCNN and Hybrid Spectral Learning (HSL) blocks, and an expert-routing head for component-level estimation of AL, SPH, and CYL. On a pediatric cohort of 4,359 eligible child visits and 6,966 fundus images, SpecF2M outperforms controlled CNN/ViT baselines for AL and SPH estimation, achieving MAEs of 0.5347 mm and 0.7062 D, respectively. Component-level analysis further reveals asymmetric task coupling, where CYL exhibits weaker association with fundus-derived myopic patterns than AL/SPH. These results support fundus-based, screening-oriented estimation of pediatric myopia indicators, while external validation remains necessary before deployment.
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