对比两种病理AI分析策略,指导有限资源下如何选择最佳方案。
An Information Theory Analysis of Whole Slide Image Pathology AI and Diagnostic Field Selection AI Under Limited Resources
- 用粗略视图判断病变位置信息,决定采用全片分析或局部选区分析
- 小肿瘤灶在淋巴结中因定位不清时,全片分析更优;背景不均时选区分析优势更大
- 空间连续病灶需完整刻画时,选区分析可利用结构信息提升诊断质量
病理AI诊断中的核心问题是:应向AI提供哪些图像信息,以及如何在资源受限条件下高效利用分析能力。本研究对比了两种方法:全切片图像AI(WSI-AI)自动压缩全片信息进行分析,和诊断区域选择AI(DFS-AI)由专家先选定若干区域、放大倍数与比较项,再由AI分析。构建三种图像模型:罕见局灶性病灶、非均匀背景下的病灶检测、空间连续性病灶。结果表明:当粗略视图无法提供病变位置线索(如淋巴结中极小肿瘤灶),WSI-AI表现更优;若粗略视图已提供有效定位信息,在中等资源范围内DFS-AI更佳;在非均匀背景中寻找特定病原体时,DFS-AI相对价值更高;对于空间连续性病灶,随着病灶增大,WSI-AI更易发现病灶;但要全面刻画整个病灶,DFS-AI因能利用连续结构选择分析区域而更具优势。结论指出,两者相对性能随粗略视图提供的位置信息、背景异质性、局部上下文及病灶空间结构系统性变化。实际应用中,医生应根据诊断任务的信息结构选择合适策略。
原文摘要 · Abstract (English)
A key issue in using AI for pathology diagnosis is what image information should be given to the AI and how limited analysis resources should be used. This study compares two ways of processing different types of images under limited resources. The first is WSI-AI, in which AI automatically compresses information from the whole slide image (WSI). The second is Diagnostic Field Selection (DFS)-AI in which an expert first selects several regions, magnifications, and comparisons needed for diagnosis, and the AI then analyzes those selected fields. To compare these two types, we built three image models: a rarely localized lesion, lesion detection in a nonuniform background, and a spatially continuous lesion. As a result, WSI-AI was better when a coarse view did not give enough information about lesion location in advance, as may occur with very small tumor foci in lymph nodes. In contrast, when a low-cost coarse view provided useful location information, DFS-AI was better in an intermediate range of limited resources. When searching for a specific object such as infectious organism in a nonuniform background, the relative value of DFS-AI increased. For spatially continuous lesions, WSI-AI found the presence of a lesion more easily as the lesion became larger. However, for complete characterization of the entire lesion, DFS-AI could be better because it used the continuous structure to select fields for analysis. In conclusion, both relative performance changes in a systematic way with location information from the coarse view, background heterogeneity, local context, and the spatial structure of the lesion. A practical strategy under limited resources is for physicians to choose between WSI-AI and DIS-AI according to the information structure of the diagnostic task.
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