处理图像等结构化结果的因果推断,解决因设备差异导致的误判问题。
Causal inference for group-contaminated structured outcomes: observable quotients, lossless reduction and exact randomization inference
- 通过商空间降维保留关键信息,实现无损统计分析
- 在真实数据中检验出0.0078的显著性,模拟显示99.2%检出力
- 适用于生物成像等受设备变换干扰的多中心研究
当显微图像等结构化潜在结果在未知且个体特异的变换后被记录时,若该变换依赖于处理、协变量或内在结果,原始坐标分析可能混淆生物学效应与采集几何。我们研究了通用观测模型 X = Γ . Y(A),刻画其可观测信息:目标在群轨道上恒定时可精确恢复,而Borel最大不变量保留所有可测不变目标。进一步区分可观测性与统计无损性。商忠实重构定理表明,仅当给定处理、协变量和商的原始观测条件分布存在无参数版本时,商缩减才足以完整还原实验。紧群上的条件哈尔污染是黑威尔等价的特例,但不强加于主模型。我们还区分了独立站点乘积作用与共享对角作用,并说明分量规范可能丢失跨站点相对信息。在显式度量与核正则条件下,近似污染定理界定了商分布的Wasserstein误差及诱导的总体MMD扰动。针对有限支持多通道格点图像,我们构造了整数平移与四分之一旋转下的最大不变量,结合特征高斯核与完全配对交换检验,保留原始模拟与RxRx1 HUVEC研究。在严格零假设下,商检验在0.052次模拟重复中拒绝;单位效应强度下检验功效达0.992。主要RxRx1对比的配对交换p值为0.0078。
原文摘要 · Abstract (English)
Structured potential outcomes such as microscopy images may be recorded after an unknown, unit-specific transformation. If that transformation can depend on treatment, covariates or the intrinsic outcome, raw-coordinate analyses may mix biological effects with acquisition geometry. We study the unrestricted observation model X = Γ . Y(A) and characterize its observable information: a target is uniformly recoverable exactly when it is constant on group orbits, while a Borel maximal invariant retains every measurable invariant target. We then distinguish observability from statistical losslessness. A quotient-faithful reconstruction theorem shows that quotient reduction is sufficient for the full transformed experiment exactly when the conditional law of the raw observation given treatment, covariates and the quotient has a parameter-free version. Conditional Haar contamination on a compact group yields Blackwell equivalence as a special case; it is not imposed in the main model. We also separate independent site-specific product actions from shared diagonal actions and show why componentwise canonicalization can discard relative cross-site information. Under explicit metric and kernel regularity, an approximate-contamination theorem bounds quotient-law Wasserstein error and the induced perturbation of population maximum mean discrepancy. For finite-support multichannel lattice images, we construct a maximal invariant under integer translations and quarter turns, combine its characteristic Gaussian kernel with a complete paired-swap test, and retain the original simulations and RxRx1 HUVEC study. Under the sharp null, the quotient test rejected in 0.052 of simulation replicates; at unit effect strength its power was 0.992. The primary RxRx1 contrast had an enumerated paired-swap p-value of 0.0078.
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