构建可审计的AI系统,实现甲状腺超声诊断全流程协同与临床可纠错。
Auditable agentic AI for evidence-grounded thyroid ultrasound diagnosis and reporting

- 设计多工具协作的智能体系统,统一处理病灶定位、测量与报告生成。
- 在多个数据集上实现87.2%分割准确率和0.947分类鲁棒性,报告质量优于基线。
- 支持医生参与修正,提升诊断一致性并显著缩短工作耗时。
甲状腺超声诊断需协调病灶定位、测量、风险分层与报告生成,但现有AI系统多孤立处理任务且难以支持临床复核。本文提出ThyroidXAgent,一种面向临床交互的智能体AI系统,整合专用诊断工具,并以可审计的病例级证据记录存储输出结果。系统基于OpenThyroidDB构建,该资源包含约30万张超声图像与2.4万份配对报告,测试覆盖28,458个非重叠病例,包括来自35家中心的私有NHC-MISD-TUS队列中8,721例。在异构数据集上,ThyroidXAgent实现病灶分割平均Dice分数87.21%,良恶性分类平均AUROC 0.9466;同一流程支持淋巴结转移预测(AUROC 0.864)与滤泡癌/乳头状癌分类(AUROC 0.805)。报告生成采用基于证据的结构化组装,优于多模态语言模型基线。本文引入的ThyClinScore(病变级临床语义度量)与位置感知语言模型判别器相关性最强。使用后医生分类准确率提升,报告诊断一致性从70.3%增至86.2%,分割与报告时间分别减少35.9%与27.4%。研究证实了可审计、可由医生修正的智能体AI在甲状腺超声诊断中的可行性。
原文摘要 · Abstract (English)
Thyroid ultrasound diagnosis requires coordinated lesion localization, measurement, risk stratification and reporting, yet most AI systems address these tasks in isolation and provide limited support for clinical review. We present ThyroidXAgent, a clinician-interactive agentic AI system that coordinates specialized diagnostic tools and stores their outputs as an auditable case-level evidence record. The system was developed using OpenThyroidDB, a multicentre, multitask resource integrating approximately 0.3 million ultrasound images and 24,000 paired reports, and was evaluated on 28,458 non-overlapping test cases, including 8,721 cases from 35 centres in the private NHC-MISD-TUS cohort. Across heterogeneous datasets, ThyroidXAgent achieved a mean Dice score of 87.21 percent for nodule segmentation and a mean AUROC of 0.9466 for benign-malignant classification. The same workflow supported lymph-node metastasis prediction and follicular versus papillary thyroid carcinoma classification, with AUROCs of 0.864 and 0.805, respectively. For report generation, evidence-grounded assembly outperformed multimodal language-model baselines across three cohorts. ThyClinScore, a lesion-level clinical semantic metric introduced here, showed the strongest correlation with a location-aware language-model judge. ThyroidXAgent improved physician classification accuracy, increased report diagnostic consistency from 70.3 percent to 86.2 percent, and reduced segmentation and reporting time by 35.9 percent and 27.4 percent, respectively. These findings support auditable, clinician-correctable agentic AI for thyroid ultrasound diagnosis and reporting.
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