让大模型代理自动进化防御能力，应对新型安全威胁。

The expanding operational capabilities of large language model (LLM) agents introduce sophisticated security threats. Runtime defenses have emerged as an effective approach to mitigating these risks by integrating security mechanisms into the agent execution loop. However, existing runtime defenses rely heavily on manually designed interventions and lack a principled framework for their construction and maintenance. In this work, we first develop a harness-level formulation of runtime defense that systematically characterizes how harness mechanisms enable defense construction and provides a unified view of existing runtime defense interventions from a harness perspective. Building on this formulation, we propose HARD (Harness-based Autonomous Runtime Defense Evolution), a self-evolving runtime defense framework that automatically identifies appropriate intervention strategies and iteratively improves defense artifacts based on observed failure traces. HARD transforms runtime defense development from manual engineering into an autonomous evolution process, and extensive experiments demonstrate that it improves security performance over existing handcrafted defenses while preserving benign task utility. Our findings highlight autonomous defense evolution as a promising new paradigm for securing deployed LLM agents, enabling agents to identify defense weaknesses and continuously improve their protection mechanisms.