arXiv:2608.16029cs.LGstat.ME2026-08

新算法同时发现共性与个体脑网络,提升临床神经影像敏感性。

Group ICA 2.0: Closing the Gap Between Subjects and Group Latent Decomposition with Copula-Linked Group ICA (CoLiG-ICA)

  • 用耦合模型联合建模共享与个体特有脑网络
  • 在精神分裂症数据中发现3个传统方法遗漏的脑网络
  • 适合研究个体差异显著的临床群体,如精神疾病

组独立成分分析(gICA)广泛用于分解高维功能磁共振数据以识别可解释的脑网络。然而传统gICA主要捕捉跨被试共享的成分,限制了仅存在于个别被试或子群体中的网络恢复,降低了对临床神经影像中个体异质性的敏感性。本文提出耦合链接组ICA(CoLiG-ICA),在Group ICA 2.0框架下,统一建模模板约束、队列特有和被试特有脑网络。CoLiG-ICA融合基于ICA的空间分解、基于耦合器的依赖建模与深度学习优化,在保持模板约束成分一致性的同时,允许超越参考网络的自由成分。通过将被试分解与共享模板关联,并联合估计队列特有与被试特有源,有效表征传统组先验未覆盖的个体变异性。在UCLA-CNP数据集上评估,相比传统约束ICA,CoLiG-ICA在估计模板关联成分、发现额外自由成分、提升成分独立性及捕捉被试层面变异方面表现更优。相比MOO-ICAR,CoLiG-ICA显著降低成分间空间依赖性,且显著减少模板关联成分中的运动伪影方差。在仅精神分裂症群体分析中,识别出53个模板关联的NeuroMark成分外的3个新网络:1个感觉运动网络和2个视觉网络。

原文摘要 · Abstract (English)

Group Independent Component Analysis (gICA) is widely used to decompose high-dimensional functional MRI data into interpretable brain networks. However, conventional gICA primarily identifies components shared across subjects. This group-level assumption can limit the recovery of networks present only in individuals or subject subsets, reducing sensitivity to intersubject heterogeneity in clinical neuroimaging datasets. We introduce Copula-Linked Group ICA (CoLiG-ICA), an algorithm in the Group ICA 2.0 framework that jointly estimates template-linked, cohort-only, and subject-only brain networks within a unified model. CoLiG-ICA combines ICA-based spatial decomposition, copula-based dependence modeling, and deep learning optimization to preserve the consistency and interpretability of template-constrained ICA while enabling free components beyond the reference networks. By linking subject decompositions to shared templates and jointly estimating cohort-only and subject-only sources, CoLiG-ICA represents individual variability not captured by conventional group priors. We evaluate CoLiG-ICA using resting-state fMRI data from the UCLA-CNP dataset and compare it with conventional constrained ICA in estimating template-linked components, discovering additional free components, improving component independence, and capturing subject-level variability beyond the shared group prior. Compared with MOO-ICAR, CoLiG-ICA showed significantly lower intercomponent spatial dependence, indicating improved subject-level component independence, and significantly reduced motion-related variance in the template-linked components. Additionally, in a schizophrenia-only group analysis, CoLiG-ICA identified three additional resting-state networks beyond the 53 template-linked NeuroMark components: one sensorimotor and two visual networks.

脑网络分析功能性MRI个体差异精神分裂症

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