用3D深度学习精准定位膝关节前交叉韧带骨隧道，提升重建手术成功率。

One of the most common reasons for anterior cruciate ligament (ACL) reconstruction failure is femoral tunnel malpositioning (ACL footprint center and tunnel orientation). Such failures may lead to the development of meniscal pathology and osteoarthritis. Accurate ACL femoral footprint identification is therefore essential for precise tunnel placement, restoration of the native knee joint mechanics, post-surgical knee joint health and prevention of graft failure. Recent advances in artificial intelligence (AI) bring new opportunities to improve image-guided orthopedic surgery. However, at present, existing AI research focuses primarily on ACL segmentation and rupture classification based on pre- and post-operative magnetic resonance (MR) images. Identification of the ACL footprint center using deep learning methods has not been thoroughly researched. Thus, the purpose of this study is to explore 3D deep learning models for ACL femoral footprint identification directly from 3D MR images. Two comprehensive 3D deep learning architectures were developed: a 3D graph convolutional neural network-based geometric model applied to 3D femoral meshes; and a 3D landmark-enhanced identification model based on 3D MR images. A total of 4883 right and 3087 left knee image sets were used from a publicly available database. Eighty percent (80%) were applied to model generation, and twenty percent (20%) were preserved for model testing. Both models achieved excellent performance; however, the image-based method outperformed the model-based method (average error of 2.1mm vs 2.8 mm). Thus, 3D deep learning provides a feasible clinical approach for ACL footprint localization and has the potential to improve ACL reconstruction footprint accuracy.