实现加速超1000倍的动态心脏核磁重建，无需训练数据

Purpose: To develop and evaluate a self-supervised dynamic reconstruction framework for highly undersampled dual-echo three-dimensional late gadolinium enhancement (3D LGE) MRI. Methods: MOSAIC jointly models multi-echo image content, coil sensitivity maps, and beat-specific nonrigid motion directly from acquired undersampled data, without requiring fully sampled training datasets or accurate precomputed sensitivity maps. Unlike existing methods that bin the acquired data into different motion states, with or without motion compensation, MOSAIC reconstructs a motion-resolved 3D LGE image from each heartbeat. The method was evaluated using digital phantoms with simulated myocardial scars and in vivo animal and human studies. Results: In phantom experiments, MOSAIC achieved higher peak signal-to-noise ratio and structural similarity index measure than low-rank deep image prior reconstruction and ablation variants of MOSAIC. In animal and human studies, MOSAIC achieved higher blinded expert image-quality scores than inline image-navigated compressed-sensing and low-rank deep image prior reconstructions. Conclusion: MOSAIC demonstrated the feasibility of motion-resolved free-breathing dual-echo 3D LGE MRI at acceleration factors exceeding 1,000, with improved detail preservation and artifact suppression relative to the state-of-the-art comparison methods.