用流匹配提升低剂量PET图像重建质量,改善偏差-方差权衡。
Flow Matching-Based PET Image Reconstruction

- 基于流匹配直接从中间状态生成清晰图像,分离数据一致性与生成过程。
- 在[18F]FDG脑部PET数据上,各剂量水平下均优于现有方法。
- 适合做定量PET重建的生成先验,尤其适用于低剂量场景。
生成模型在正电子发射断层扫描(PET)图像重建中展现出巨大潜力。尽管基于扩散模型的方法表现良好,但通常需要大量反向采样步骤,并将数据一致性更新嵌入采样过程。流匹配提供了一种有吸引力的替代方案:可直接从中间状态估计干净图像,使数据一致性精炼与流传播分离。本文提出基于流匹配的PET图像重建方法。首先,在FlowDPS框架中引入泊松似然引导和基于期望最大化(EM)的预处理器,构建PET-FlowDPS。随后,提出一种基于模型的重建方法,利用预训练的流匹配模型作为先验,将基于流的先验、PET数据精炼与随机传播统一于近似贝叶斯框架中。在[18F]FDG脑部PET数据集上的实验结果表明,所提方法在不同剂量水平下均实现了更优的偏差-方差权衡,验证了流匹配作为定量PET重建生成先验的潜力。
原文摘要 · Abstract (English)
Generative models have shown strong potential for positron emission tomography (PET) image reconstruction. Although diffusion model-based reconstruction methods have demonstrated promising performance, they often require many reverse sampling steps with data-consistency updates incorporated into the sampling process. Flow matching offers an attractive alternative because it can directly estimate clean images from intermediate states, allowing data-consistency refinement to be separated from flow propagation. In this work, we proposed flow matching-based PET image reconstruction methods. We first established PET-FlowDPS by incorporating Poisson likelihood guidance with an expectation-maximization (EM)-based preconditioner into the FlowDPS framework. We then proposed a model-based PET reconstruction method that used a pretrained flow matching model as a prior, in which the flow-based prior, PET data refinement, and stochastic propagation were interpreted within an approximate Bayesian framework. Experimental results using [$^{\text{18}}\text{F}$]FDG brain PET datasets showed that the proposed method achieved better bias-variance trade-offs across different dose levels compared with other reference methods. These results demonstrated the potential of flow matching as a generative prior for quantitative PET image reconstruction.
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