arXiv:2608.20305cs.CV2026-08

通过自适应课程学习提升心肌瘢痕分割精度,尤其适合低对比度小病灶场景。

CalcSeg: Confidence-aware 3D Latent Context Curriculum Learning For Myocardial Scar Segmentation From Single-Stack LGE-CMRs

论文配图:CalcSeg: Confidence-aware 3D Latent Context Curriculum Learning For Myocardial Scar Segmentation From Single-Stack LGE-CMRs
图 1 · 摘自论文原文
  • 用置信度评分自动筛选难易样本,动态调整训练策略
  • 在多中心数据上显著优于现有方法,小瘢痕和弥散病灶提升明显
  • 适合临床挑战性病例,对单层扫描数据有强鲁棒性

从单层延迟增强心脏磁共振(LGE-CMR)图像中进行心肌瘢痕分割是长期存在的临床难题,尤其在组织对比度低、瘢痕弥散或微小的情况下。由于单层扫描导致三维空间上下文有限,该问题更加严峻。本文提出CalcSeg,一种基于置信度感知的3D潜在上下文课程学习框架,利用单层2D LGE-CMR图像融合生成的3D特征表示实现鲁棒分割。我们设计了一种动态半监督课程学习策略,通过学习的置信度评分函数,从较易病例逐步过渡到更难病例进行训练;该函数结合预测瘢痕图的误差、量化认知不确定性及瘢痕负荷估计,无需人工标注即可自动评估样本难度。为弥补单层采集的空间限制,我们引入潜在的逐片自注意力机制,从稀疏二维输入中捕捉跨切片依赖关系,推断三维空间表征。在多个中心临床LGE-CMR数据集上的实验表明,CalcSeg始终优于现有分割网络,尤其在临床挑战性病例上表现突出。代码已开源。

原文摘要 · Abstract (English)

Myocardial scar segmentation from single-stack late gadolinium-enhanced cardiac magnetic resonance (LGE-CMR) imaging has been a longstanding and clinically important challenge, particularly in the presence of low tissue contrast, diffuse, and small scar regions. These challenges are further intensified by the limited availability of 3D spatial context. This paper presents CalcSeg, a Confidence-aware latent context curriculum learning framework that leverages fused 3D feature representations from single-stack 2D LGE-CMR images for robust scar segmentation. Specifically, we introduce a dynamic semi-supervised curriculum learning strategy that progressively expands training from easier to more challenging scar cases using a learned confidence-aware scoring function. Such a function integrates errors in the predicted scar maps with quantified epistemic uncertainty and scar burden estimation to automatically assess sample difficulty without requiring manual labels. To compensate for the limited spatial context in single-stack acquisitions, we then develop a latent slice-wise self-attention to capture inter-slice dependencies and infer 3D spatial representations from sparse 2D inputs. We evaluate CalcSeg on multi-center clinical LGE-CMR datasets and benchmark against existing scar segmentation networks. Experimental results show that CalcSeg consistently outperforms all competing methods, particularly with substantial improvements on clinically challenging cases. Our code is released on Github.

心肌分割弱监督医学影像自注意力

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