arXiv:2608.20380q-bio.NCcs.LG2026-08

将脑功能连接分解为冗余、独特与协同三类信息,提升疾病诊断可解释性。

Interpretable Information-Decomposed Brain Graph Learning for fMRI-based Disease Diagnosis

论文配图:Interpretable Information-Decomposed Brain Graph Learning for fMRI-based Disease Diagnosis
图 1 · 摘自论文原文
  • 用部分熵分解分离脑区间的冗余、独特和协同信息
  • 在三个数据集上均超越传统连接方法,提升诊断性能
  • 揭示疾病特异的信息组织变化,适合神经疾病研究者

静息态功能磁共振成像(rs-fMRI)实现了脑功能交互的无创映射,用于辅助疾病诊断。然而,现有方法多将脑区间关系简化为基于相关性的边权重,仅反映同步波动强度,忽略了信息实际传递方式。脑疾病可能不仅改变连接强度,还影响冗余、独特性和协同性等信息组织结构。为此,本文提出IID-GCN框架,通过部分熵分解将rs-fMRI交互分解为冗余、独特和协同三类图,分别刻画共享、区域特异和联合涌现的脑活动成分。再通过多通道图卷积网络进行边重校准、跨信息交互、ROI注意力读出和通道注意力融合。在三个数据集上,该方法持续捕获传统功能连接之外的互补诊断信息。学习到的信息谱揭示了疾病特异的冗余、独特性和协同性改变模式,表明脑疾病重塑了功能信息组织,而非仅改变连接强度。结果确立了信息分解脑图为可解释的rs-fMRI诊断表示。代码已开源:https://github.com/Zdy12/IID-GCN。

原文摘要 · Abstract (English)

Resting-state functional magnetic resonance imaging (rs-fMRI) has enabled non-invasive mapping of functional brain interactions for computer-aided diagnosis, yet most existing approaches reduce inter-regional relationships to correlation-based edge weights. Such representations capture co-fluctuation strength but obscure how information is shared across brain regions. Because brain disorders may disrupt not only connectivity strength but also the organization of redundancy, uniqueness and synergy, traditional functional connectivity may miss disease-relevant information structures. Here we introduce IID-GCN, an interpretable graph learning framework that decomposes rs-fMRI interactions into redundancy, uniqueness and synergy graphs using partial entropy decomposition. These information-specific graphs separately characterize shared, region-specific and jointly emergent components of brain activity. A multi-channel graph convolutional network then integrates the decomposed graphs through edge recalibration, cross-information interaction, ROI-attention readout and channel-attentive fusion. Across three datasets, IID-GCN consistently captures complementary diagnostic information beyond traditional functional connectivity. The learned information profiles reveal disorder-specific patterns of altered redundancy, uniqueness and synergy, suggesting that brain diseases reshape functional information organization rather than merely changing connection strength. These results establish information-decomposed brain graphs as an interpretable representation for rs-fMRI-based diagnosis. Our code is available at https://github.com/Zdy12/IID-GCN.

脑图谱可解释性功能连接fMRI

Thank you to arXiv for use of its open access interoperability. PaperDance 不是 arXiv 官方产品;中文卡片由大模型生成,请以原文为准。