arXiv:2608.21060cs.AIcs.CV2026-08

首个病理全切片细胞级评估基准,可系统检验模型对细胞类型信息的解码与迁移能力。

CellPath-Bench: A Multidimensional Benchmark for Whole-Slide Cellular Representations in Pathology Foundation Models

论文配图:CellPath-Bench: A Multidimensional Benchmark for Whole-Slide Cellular Representations in Pathology Foundation Models
图 1 · 摘自论文原文
  • 基于25组空间对齐的H&E-Xenium切片,构建细胞级评估体系
  • 30个模型在700万+细胞上测试,揭示显著的跨器官泛化差异
  • 提供标准化框架,适合评估病理大模型的细胞表征质量

病理基础模型(PFM)正作为通用骨干广泛使用,但现有评估基准无法系统诊断其全切片细胞表征能力,包括细胞类型信息的可解码性及跨组织切片、数据集和解剖器官的可迁移性。我们提出CellPath-Bench,一个细胞分辨率的评估基准,用于评估冻结的PFM自身表现。经52个候选Xenium数据集的质量控制后,构建由25组空间对齐的H&E-Xenium组织切片组成的面板,覆盖11个器官,包含7,079,283个细胞,并统一为细粒度与粗粒度分类体系。该基准在注册的核坐标处采样全切片图像(WSI)特征图,使用标准多类线性探测器进行评估。细胞表征优势(CRA)衡量以核为中心的表示相对于块级平均池化的内部切片优势;细胞表征可迁移性(CRT)刻画细胞类型解码能力在切片、数据集和器官间的泛化性能。通过304,920次运行,对30个病理专用与通用基础模型进行评估,结果显示模型间在细胞类型解码能力及其跨域泛化上存在显著差异,呈现出独特的多维能力画像。CellPath-Bench为审计冻结的病理基础模型中的细胞信息提供了标准化框架。

原文摘要 · Abstract (English)

Pathology foundation models (PFMs) are increasingly used as general-purpose backbones, yet existing benchmarks cannot systematically diagnose their whole-slide cellular representation capabilities, including the decodability of cell-type information and the transferability of such information across tissue sections, datasets, and anatomical organs. We introduce CellPath-Bench, a cellular-resolution benchmark that evaluates frozen PFMs themselves. Following quality control of 52 candidate Xenium datasets, we construct a panel of 25 spatially aligned H\&E--Xenium tissue sections spanning 11 organs and 7,079,283 cells, harmonized into fine- and coarse-grained taxonomies. CellPath-Bench samples frozen WSI feature maps at registered nuclear coordinates and evaluates them using standardized multiclass linear probes. Cell Representation Advantage (CRA) measures the within-section advantage of nucleus-anchored representations over patch-level mean pooling, while Cell Representation Transferability (CRT) characterizes the generalization of cell-type decodability across tissue sections, datasets, and organs. We benchmark 30 pathology-specific and general-purpose foundation models through 304,920 runs across spatial readouts, magnifications, taxonomic granularities, and evaluation protocols. The results reveal substantial model-dependent differences in cell-type decodability and its cross-domain generalization, yielding distinct multidimensional capability profiles. CellPath-Bench provides a standardized framework for auditing cellular information in frozen PFM representations.

病理模型细胞表征评估基准多器官泛化

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