合成纵向电子病历,让生成数据更真实、更符合临床规律。
SynEHR: Joint Modeling Inter-visit Temporal Evolution and Intra-visit Clinical Structure for Longitudinal EHR Synthesis

- 用动态状态建模捕捉就诊间时间不规则变化
- 生成数据在临床一致性和时间真实性上超越现有方法
- 适合医疗数据生成、隐私保护研究者使用
纵向电子健康记录(EHR)记录患者随时间的多次就诊序列,体现疾病进展与诊疗过程。但真实数据因包含大量敏感个体信息而难以获取。合成EHR可保留统计模式和临床结构,为模型训练与分析提供支持。现有生成模型虽能预测未来就诊,却未能显式整合就诊间的时间不规则演变与单次就诊内的临床事件结构,导致生成结果临床不一致、时间不真实。本文提出SynEHR,一种轻量级自适应LLM框架,包含:1)时间状态条件模块,捕捉跨就诊的不规则时间状态;2)时间-关系适配模块,将时间状态与病史结合,动态构建个性化关系表征。模型基于参数高效的LoRA微调语言模型生成器,实现下一次就诊预测。在多个真实世界EHR数据集上,综合评估其保真度、隐私性与下游任务性能,结果表明SynEHR显著优于现有先进模型,生成的数据更具临床合理性和时间忠实性。
原文摘要 · Abstract (English)
Longitudinal electronic health records (EHRs) document patients' sequences of clinical visits over time, preserving the temporal evolution of disease progression and care delivery. However, real longitudinal EHRs are difficult to access because they contain large amounts of fine-grained, patient-specific information. Synthetic EHR generation therefore provides a valuable approach for preserving the statistical patterns and clinical structure of patient visit trajectories, enabling broader modeling and analysis when real records are limited. Although recent generative models have made progress in producing future visit sequences, they remain limited in explicitly integrating inter-visit irregular temporal evolution and intra-visit clinical event structures in EHRs, leading to clinically inconsistent and temporally unrealistic visit sequences. In this work, we propose SynEHR, a lightweight adaptive LLM-based framework for longitudinal EHR synthesis. There are two novel designs in SynEHR, i.e., a Temporal State Conditioning Module captures irregular temporal states across visits and a Temporal-Relational Adaptation Module combines these states with patient history to dynamically construct patient-specific relational representations. SynEHR then builds on a parameter-efficient LoRA-adapted language-model generator with next-visit generation capability to train the two modules for temporally and clinically informed generation. Extensive experiments on real-world EHR datasets across fidelity, privacy, and downstream utility evaluations demonstrate that SynEHR outperforms state-of-the-art models by generating more clinically coherent and temporally faithful longitudinal EHR data.
Thank you to arXiv for use of its open access interoperability. PaperDance 不是 arXiv 官方产品;中文卡片由大模型生成,请以原文为准。