arXiv:2608.21813cs.CV2026-08

用薛定谔桥模型修复死后自溶的病理图像,提升法医诊断客观性。

Through the Schrödinger Bridge: Benchmarking Antemortem Image Restoration from Postmortem Autolysis to Enhance Forensic Diagnostics

论文配图:Through the Schrödinger Bridge: Benchmarking Antemortem Image Restoration from Postmortem Autolysis to Enhance Forensic Diagnostics
图 1 · 摘自论文原文
  • 将自溶图像恢复为术前状态,采用无配对数据的薛定谔桥建模。
  • 构建首个同源无配对数据集AutoPath,含近万张10倍放大切片。
  • 提出基于诊断分布一致性的评估方法,超越传统生成指标。

法医组织病理学对死因判定与疾病诊断至关重要,但死后自溶(不可逆、随机的组织退化)严重扭曲形态结构,引入诊断主观性。本文提出在无配对监督下,将严重自溶的尸检图像恢复为具有诊断意义的术前表征。为此,我们构建了AutoPath——首个同源无配对数据集,通过将标本分为相邻组织块(一立即处理,一诱导自溶),从69例肝病样本中获取近一万张10×放大图像块。问题被形式化为自溶与非自溶分布间的薛定谔桥,提供对随机且严重形态退化的合理建模。关键发现:通用图像级生成指标(如FID)与诊断实用性不匹配,提出基于幻灯片级诊断分布一致性的法医导向评估方法。本工作建立可复现基准,涵盖任务定义、真实世界数据集与评估方法,推动法医病理自溶修复向严谨且实际有意义的方向发展。

原文摘要 · Abstract (English)

Forensic histopathology, essential for determining cause of death and disease diagnosis, is severely impeded by postmortem autolysis, i.e., an irreversible, stochastic degradation process that distorts tissue morphology and introduces diagnostic subjectivity, thereby underscoring the value of restoring autolyzed images to a diagnostically plausible, pre-autolysis state for improving objectivity in forensic practice. This restoration task is fundamentally challenging due to the large, non-deterministic morphological changes caused by autolysis and the infeasibility of pixel-wise paired data, which invalidates assumptions underlying supervised and cycle/structure-consistent unpaired translation methods. To address this, we formalize forensic histopathology autolysis restoration as a new task: under unpaired supervision, transform postmortem images with severe autolysis into diagnostically meaningful ``antemortem'' representations. We contribute AutoPath, the first homologous yet unpaired dataset for this problem, constructed by splitting specimens into adjacent tissue blocks---one processed immediately, the other exposed to induce autolysis---yielding nearly ten thousand $10\times$ patches from 69 cases with varying liver conditions. We further frame the problem as a Schrödinger Bridge between the autolyzed and non-autolyzed distributions, offering a principled approach to modeling stochastic, severe morphological degradation. Critically, we demonstrate the misalignment of generic image-level generative metrics (e.g., FID) with diagnostic utility and propose a forensically grounded, slide-level diagnostic distribution consistency evaluation. Overall, this work establishes a reproducible benchmark (encompassing task definition, a real-world dataset, and an evaluation methodology) toward rigorous and practically meaningful progress in autolysis restoration for forensic pathology.

法医病理图像修复生成模型薛定谔桥

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