arXiv:2608.22583cs.LGcs.AI2026-08中稿 · WM@Booth 2026

用预测性图模型构建可修正的临床知识图谱,提升医疗决策支持可靠性。

Clinical Graph-JEPA: Predictive Patient-State Knowledge Graphs for Cognitive Decision Support

论文配图:Clinical Graph-JEPA: Predictive Patient-State Knowledge Graphs for Cognitive Decision Support
图 1 · 摘自论文原文
  • 通过多智能体关系提议与JEPA隐式优化,动态构建患者状态图
  • 在MIMIC-IV数据上,注入病程记录嵌入使关系恢复准确率提升31%
  • 适合医疗AI研发者、临床决策系统设计者参考

临床记录包含丰富的患者状态信息,但将其转化为可靠且结构化的知识图谱仍具挑战,因抽取错误、本体不匹配、关系缺失和时间模糊性会传递至下游系统。本文提出一种临床知识图谱构建与精炼框架,结合多智能体关系提议、本体感知归一化、确定性证据评分及基于JEPA的隐式精炼。不将临床知识图谱视为静态提取产物,而是作为预测性的患者状态表征。每次入院时,系统从结构化MIMIC-IV记录和推断的临床跨链接中构建带证据得分的图,并学习从观察到的图上下文中恢复被遮蔽的临床关系。采用无泄漏的留一法边恢复(MRR与Hits@k)及留出批处理掩码评估(AUC与MRR)。为隔离出院记录上下文的影响,比较无病程嵌入配置与仅向病程锚定实体注入真实出院记录表示的增强配置。在相同队列与评估协议下,实体锚定的病程注入使整体留一法MRR相对提升31%。

原文摘要 · Abstract (English)

Clinical records contain rich evidence about patient state, but converting that evidence into reliable, structured knowledge graphs remains difficult because extraction errors, ontology mismatch, missing relations, and temporal ambiguity can propagate into downstream systems. We propose a clinical knowledge graph construction and refinement framework that combines multi-agent relation proposal, ontology-aware normalization, deterministic evidence scoring, and JEPA-based latent refinement. Rather than treating a clinical knowledge graph as a static extraction artifact, we treat it as a predictive patient-state representation. For each admission, the system constructs an evidence-scored graph from structured MIMIC-IV records and inferred clinical cross-links, then learns to recover held-out clinical relations from the observed graph context. We evaluate the refiner with leakage-free leave-one-out edge recovery (MRR and Hits@k) and held-out batch-mask evaluation (AUC and MRR). To isolate the contribution of discharge-note context, we compare a note-embedding-free configuration with a note-augmented configuration that injects real discharge-note representations only into note-grounded entities. Under the same cohort and evaluation protocol, entity-grounded note injection improves overall leave-one-out MRR by 31% relative improvement.

临床图谱知识图谱医疗AIJEPA

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