用深度学习自动修复微CT成像中的抖动伪影,无需参考图像。
Differentiable Jitter Correction using Deep Learning-based Image Quality Metric for Phase-Contrast Micro-CT

- 基于图像质量度量的可微分优化,直接从投影数据中估计并校正抖动。
- 在模拟和真实数据上均恢复了因抖动丢失的细微结构细节。
- 适用于生物样本,跨不同样本形态具有良好泛化能力。
本文提出一种全可微分的抖动校正方法,用于X射线相位对比微计算机断层扫描。该方法利用基于深度学习的图像质量度量,直接从采集的投影数据中估计并补偿每幅投影的刚性抖动,无需预先获取无运动干扰的参考数据。方法基于适配于平行光束几何的梯度自聚焦策略,通过受控实验对比多种候选目标函数,并验证了视觉信息保真度(VIF)度量对抖动伪影的敏感性。为实现无参考运行,训练了一个紧凑的3D卷积神经网络,从单个受损体数据预测VIF分数。引入仅作用于图像背景的空间选择性总变差惩罚项,以抑制优化过程中产生的虚假高频结构。在不同同步辐射光束线采集的生物样本上进行实验,评估采用模拟和实际采集的投影数据施加抖动的情况。结果表明,集成流程能可靠恢复因抖动损失的精细结构,且在形态差异显著的样本间表现出良好泛化能力。
原文摘要 · Abstract (English)
This paper proposes a fully differentiable jitter correction method for X-ray phase-contrast micro computed tomography using a deep learning-based image quality metric that estimates and compensates per-projection rigid jitter directly from the acquired projection data, without a pre-scan motion-free reference. The approach builds on a gradient-based auto-focus strategy adapted to parallel-beam geometry. A set of candidate objective functions is benchmarked in a controlled study, and the sensitivity of the visual information fidelity (VIF) metric to the jitter artifact is verified with the target phase-contrast data. To operate without a clean reference, a compact 3D convolutional neural network is trained to predict the VIF score from a single corrupted volume. A spatially selective total variation penalty applied exclusively to the image background is introduced to penalize spurious high-frequency structures that otherwise emerge during optimization. Experiments on biological specimens acquired at different synchrotron beamlines are conducted. Evaluation uses jitter motion applied to simulated and experimentally acquired projection data. The result confirms that the integrated pipeline reliably recovers fine structural detail lost due to jitter, with generalization demonstrated across morphologically distinct samples.
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