arXiv:2608.27483q-bio.NCcs.LG2026-08

用大脑网络的中尺度结构识别个体,更稳定且可解释。

Multiscale Community-Based Fingerprinting of Signed Functional Networks

论文配图:Multiscale Community-Based Fingerprinting of Signed Functional Networks
图 1 · 摘自论文原文
  • 基于多层社区检测,融合正负相关脑活动识别个体特异性网络结构。
  • 在HCP数据集上810名受试者中实现跨任务和会话的高精度个体识别。
  • 结果可解释性强,适合个性化神经科学与精准脑成像研究。

目的:近期研究表明,功能连接组包含可识别个体的特定签名(即‘指纹’),可在重复会话和任务间实现个体识别。现有方法多依赖对噪声敏感的边级特征,难以解释且泛化能力有限。方法:我们提出一种多尺度社区基础的功能连接组指纹框架,通过表征个体功能网络的中尺度结构来实现个体化刻画。引入一种结合正相关与负相关脑活动的有符号多层社区检测框架,以识别跨任务与会话的个体特异性社区结构。随后从联合社区结构中计算图论指标,生成低维社区层级指纹表示。结果:该框架在人类连接组计划(HCP)的810名健康对照受试者上进行评估,结果显示,基于社区的指纹能提供可靠且可解释的个体化脑特征表征,适用于跨会话与任务场景。结论:中尺度社区结构提供了有意义且具有区分性的个体特异性指纹。意义:该框架为精准神经影像与个性化神经科学研究提供了有前景的基础。

原文摘要 · Abstract (English)

Objective: Recent studies demonstrate that functional connectomes contain subject-specific signatures, or \textit{fingerprints}, that can identify individuals across repeated sessions and tasks. Existing methods mostly rely on edge-level features that are sensitive to noise, difficult to interpret, and limited in their ability to generalize across tasks and datasets. Methods: We propose a multiscale community-based functional connectome fingerprinting framework that characterizes each individual by the mesoscale structure of their functional networks. We introduce a signed multilayer community detection framework that incorporates both correlated and anti-correlated brain activity to identify subject-specific community structures across tasks and sessions. Graph-theoretic metrics are then computed from the resulting joint community structures to derive low-dimensional community-level fingerprint representations. Results: The proposed framework is evaluated on 810 healthy control subjects from the Human Connectome Project (HCP). The results show that community-based fingerprints provide a reliable and interpretable substrate for individualized brain characterization across sessions and tasks. Conclusion: Mesoscale community structure provides meaningful and discriminative subject-specific fingerprints. Significance: The proposed framework offers a promising foundation for precision neuroimaging and personalized neuroscience applications.

脑网络个体识别社区结构功能连接

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