为儿童脑瘫康复开发实时肌肉骨骼替代模型,验证其可信度与低延迟性能。
Real-Time Musculoskeletal Surrogates for Pediatric Cerebral Palsy: a Credibility Pilot

- 基于受试者条件的因果神经网络,融合运动学与真实肌力数据建模。
- 在9名患儿数据上实现92%~95%的肌腱长度预测精度,推理延迟毫秒级。
- 揭示力模型与不确定性量化是临床数字孪生的核心挑战,适合康复工程研究者。
实时肌肉骨骼(MSK)替代模型可支持儿童脑瘫(CP)的个性化康复,但其可信度依赖于个体化评估、低推理延迟和校准的不确定性。本研究采用基于OpenSim的静态参数、时间序列关节运动学、真实肌力容量及仅训练阶段扰动,构建受试者条件化的因果神经替代模型。在包含9名儿童的真实儿科脑瘫步态数据集上,使用六名发展受试者进行留一被试外验证,并对三名锁定测试受试者进行一次冻结配置评估。该模型准确重现了肌腱长度(发展验证R²=0.92,锁定受试者约0.95;nRMSE<8%),推理时间仅需亚毫秒至数毫秒,远低于100毫秒的交互式康复目标。相比之下,在小规模异质样本下,直接肌力估计仍不稳定:合并指标会高估个体内、单肌肉的准确性。蒙特卡洛可信度初步实验表明,仅传播±5%的解剖参数与肌力变化时,名义90%置信区间严重过自信(力覆盖约4%,肌腱长度覆盖低于1%)。这些结果建立了无泄漏评估与可信度框架,同时指出力建模与认知不确定性是临床可信数字孪生的关键下一步挑战。
原文摘要 · Abstract (English)
Real-time musculoskeletal (MSK) surrogates could support personalized rehabilitation for children with cerebral palsy (CP), but their credibility depends on subject-wise evaluation, low inference latency, and calibrated uncertainty. We develop a subject-conditioned causal neural surrogate using OpenSim-derived static parameters, temporal joint kinematics, true muscle capacities, and training-only perturbations. On a real pediatric CP gait dataset comprising nine children, we use leave-one-subject-out validation on six development subjects and evaluate a frozen configuration once on three locked test subjects. The surrogate accurately reproduces musculotendon lengths (R-square = 0.92 in development validation and approximately 0.95 on locked subjects; nRMSE < 8%) while requiring only sub-millisecond to few-millisecond neural inference, well below a 100 ms interactive-rehabilitation target. In contrast, direct muscle-force estimation remains unstable at this small, heterogeneous scale: pooled metrics can overstate within-subject, per-muscle accuracy. A Monte Carlo credibility pilot further shows that propagating only +/-5% anthropometry and muscle-capacity variation produces severely overconfident nominal 90% intervals (approximately 4% force coverage and below 1% MT-length coverage). These results establish a leakage-free evaluation and credibility framework for pediatric MSK surrogates, while identifying force modeling and epistemic uncertainty as the central next challenges for clinically credible digital twins.
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