让医疗AI推理更可信,防止编造证据支持的错误解释
MedAgent-R1: Faithfulness-Aware Reinforcement Learning for Evidence-Grounded Medical Reasoning
- 用信念感知强化学习,让回答必须有真实证据支撑
- 证据编造率从31.8%降至4.7%,完整率提升至82.6%
- 适合临床辅助决策系统,重视可验证性的研究者必看
当医疗AI系统产生幻觉性临床推理时,后果远不止答案错误:看似引用了检索证据的合理解释可能误导医生做出不安全的治疗决策。医疗推理代理不仅需正确答案,更要生成可由临床医生对照引用证据验证的忠实解释。我们发现强化学习训练的检索代理存在系统性失效:仅基于结果的奖励能提升准确率,却严重损害忠实度,这种现象称为‘自信幻觉’。代理学会从参数记忆中作答,并补全看似合理但无依据的解释;即便准确率比监督基线提升5个百分点,证据编造率仍从16.5%上升至31.8%。为此,我们提出信念感知奖励机制:准确率奖励需通过硬门控验证证据根基,辅以检索有效性和简洁性信号,堵住代理检索中的投机路径。所提出的MedAgent-R1系统将证据编造率从31.8%降至4.7%,证据完整率从58.7%升至82.6%,准确率保持75.1%,在HealthBench Safety上获得13.2点提升。在相同代理检索设置下,其在事实支持(4.55 vs. 4.25)和过度宣称(4.40 vs. 4.15)等忠实度维度超越GPT-4o,整体准确率仍低于其,表明显式忠实度训练带来的证据锚定效果无法仅靠模型规模实现。
原文摘要 · Abstract (English)
When medical AI systems hallucinate clinical reasoning, the consequences extend beyond incorrect answers: fabricated justifications that superficially reference retrieved evidence can mislead clinicians into unsafe treatment decisions. Medical reasoning agents must therefore produce not only correct answers but also faithful justifications that clinicians can verify against cited evidence. We identify a systematic failure mode in RL-trained retrieval agents: outcome-only rewards improve accuracy while degrading faithfulness, a phenomenon we term confident hallucination. The agent learns to answer from parametric memory and backfill plausible but unsupported justifications; citation fabrication rates rise from 16.5% to 31.8% even as accuracy improves by 5 points over the supervised baseline. We address this with a faithfulness-gated reward design: accuracy credit is conditioned on evidence grounding via a hard gate, complemented by retrieval validity and conciseness signals that close exploitation paths unique to agentic retrieval. The resulting system, MedAgent-R1, reduces citation fabrication from 31.8% to 4.7% and raises evidence completeness from 58.7 to 82.6 while maintaining 75.1% accuracy, with 13.2-point gains on HealthBench Safety. Under the same agentic retrieval setup, MedAgent-R1 outscores GPT-4o on faithfulness-specific dimensions (Factual Support 4.55 vs. 4.25; Overclaiming 4.40 vs. 4.15) while remaining below GPT-4o in overall accuracy, suggesting that explicit faithfulness training yields evidence-grounding gains not achieved by scaling alone.
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