修复脑MRI中连续损坏的图像切片,提升分析准确性。
SliceBridge: context-consistent repair of corrupted slice intervals in T1-weighted MRI
- 基于周围完整切片和位置信息,用流匹配方法重建损坏切片。
- 相比独立修复,切片间变化误差降低32.9%~41.3%,结构相似性更高。
- 适合需高精度脑部形态测量的研究者,尤其处理设备或运动导致的局部损伤。
结构性磁共振成像(MRI)常出现连续切片区域损坏,由采集、运动、硬件或重建问题导致,使部分切片与邻近切片不一致,但其余图像仍可用。此类局部损坏会误导下游形态测量分析,而丢弃或重扫图像成本高昂。本文将此问题建模为图像修复任务:给定损坏区间位置,利用周围解剖与影像上下文重建该区间切片。提出SliceBridge框架,采用条件修正流匹配,结合相邻完整切片及其相对切片位置进行重建。通过区间相关初始噪声、共享流时间与同步采样,增强切片间纵向一致性。修复后区间被无缝插入原图像,其余切片保持不变。模型在来自四个数据集的9,877例T1加权脑MRI上训练并验证,外部测试使用581名受试者,通过清除干净切片与可控损坏评估。相较于独立重建的对照模型,SliceBridge在不同区间长度下,修复区间内切片间变化误差降低32.9%~41.3%,且在所有长度上均取得更高SSIM。在可控损坏场景中,下游分割模型生成的区域脑体积估计误差中位数从损坏图像的1.95%降至1.05%。
原文摘要 · Abstract (English)
Structural magnetic resonance imaging (MRI) images are sometimes corrupted over a contiguous set of slices, where acquisition, motion, hardware, or reconstruction effects leave a single slice or short interval inconsistent with its neighbors while the rest of the image remains usable. Such localized corruption can bias downstream morphometric analysis, yet discarding or reacquiring an otherwise usable image is costly. We formulate this as an image restoration problem: given the location of the affected interval, reconstruct those slices from the surrounding anatomical and imaging context. We propose SliceBridge, a framework for restoring corrupted slice intervals in T1-weighted MRI using rectified flow matching conditioned on the surrounding intact slices and their relative slice positions. Through-plane consistency is encouraged by coupling the slices within the interval through interval-correlated initial noise, a shared flow time, and synchronized sampling. The restored interval is then inserted back, leaving all other slices unchanged. We trained and validated the model on 9,877 T1-weighted brain MRI volumes from four datasets and evaluated it on 581 external subjects using clean interval withholding and controlled corruptions. Compared with a matched model that reconstructed target slices independently, SliceBridge reduced error in slice-to-slice changes within repaired intervals by 32.9%-41.3% across interval lengths and achieved higher SSIM at every interval length. In controlled-corruption cases, SliceBridge reduced the median error in regional brain volume estimates produced by a downstream segmentation model from 1.95% in corrupted volumes to 1.05%.
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