用生成模型将大脑连接图映射到功能空间,揭示结构如何影响计算能力。
Connectome-to-Function: Conditional Generative Latent Representations for Reservoir Computing

- 构建条件生成潜空间,从连接图中学习紧凑结构表示。
- 重建准确率最高达0.910 AUC,跨实验预测性能R²达0.87。
- 适合神经科学与类脑计算研究者,可解释记忆与分类的结构机制。
连接图是神经元及其突触连接的图级映射,为理解脑回路如何支持功能与计算提供了结构基础。然而,由于这些图具有高维、稀疏且对局部结构变化敏感的特点,从连接结构推断计算功能仍具挑战性。现有方法多依赖手工设计的结构描述符或任务特定预测器,难以实现既具生成性又功能有意义的连接图表征。本文提出一种条件生成潜空间框架,将连接图编码至紧凑结构空间,并利用节点级条件引导重构与生成。该模型在连接重构上达到最高0.910的平均边重构AUC,可生成新候选连接图,实现图结构与计算行为的统一分析。以连接图作为递归计算底座,所学潜空间在储层计算实验中捕捉了功能变异,交叉验证的R²值最高约0.87。可解释性分析揭示任务特异性结构机制:记忆性能与互反馈连接相关,而预测与分类则更依赖递归网络的谱特性。这些发现表明,该方法为连接神经结构与计算能力提供了一种生成式且可解释的AI驱动范式。
原文摘要 · Abstract (English)
Connectomes, graph-level maps of neurons and their synaptic connections, provide a structural basis for understanding how brain circuits support function and computation. However, mapping connectome structure to computation remains difficult because these graphs are high-dimensional, sparse, and sensitive to local structural variation. Existing approaches often depend on hand-crafted structural descriptors or task-specific predictors, which limits their ability to represent connectomes in a form that is both generative and functionally meaningful. We propose a conditional generative latent framework that encodes connectome graphs into a compact structural space while using available node-level conditions to guide reconstruction and generation. From this space, the model can reconstruct observed connectivity with a mean edge-reconstruction AUC up to 0.910 and generate new candidate connectomes, enabling a unified analysis of graph structure and computational behavior. Using connectome-derived graphs as recurrent computational substrates, we found that the learned latent space captures functional variation across reservoir-computing experiments, with cross-validated $R^2$ values up to approximately 0.87. Interpretability analysis further revealed task-specific structural mechanisms: in our examples, memory performance is associated with reciprocal recurrent connectivity, whereas prediction and classification are more strongly associated with spectral properties of the recurrent network. These findings suggest an AI-for-science approach to linking neural connectivity to computation and provide a generative and interpretable basis for studying how distinct structural mechanisms shape computational capacity.
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