arXiv:2609.08805cs.CV2026-09

针对三叉神经痛的影像融合评估,提出以病灶区为中心的新标准。

Evaluation Principles for MRI-MRA Registration in Trigeminal Neuralgia: An ROI-Centered Neurovascular Benchmark

论文配图:Evaluation Principles for MRI-MRA Registration in Trigeminal Neuralgia: An ROI-Centered Neurovascular Benchmark
图 1 · 摘自论文原文
  • 以患者临床标注的三叉神经区域为焦点,构建局部评估基准
  • 发现传统全局配准评价指标在局部任务中常误导结果
  • 强调血管对比度和视野差异对配准效果的关键影响,适合临床医生使用

三叉神经痛术前评估常需结合结构MRI(显示三叉神经及周围蛛网膜下腔解剖)与时间飞跃MRA(突出血管结构)。尽管MRI-MRA融合有助于可视化神经血管压迫,但传统全脑配准评价无法准确反映临床需求:目标区域小、血管标注不完整且聚焦临床、局部TOF-MRA对比度变化大、视野不匹配限制可变形对齐。本文将三叉神经痛的MRI-MRA融合定义为以感兴趣区(ROI)为中心的神经血管配准-评估问题,基于149例患者的临床医师标注双侧三叉神经ROI构建基准。评估六种代表性配准流程,采用局部图像指标、分割导出的血管定位指标、预测体积分析及对比度与视野分层比较。结果显示:局部图像相似性、血管背景分离度与下游血管定位排序不一致;单侧血管距离受预测血管范围影响显著;局部MRA对比度决定血管分离度指标的有效性。可变形精修仅在视野受限时提供微弱优势,且阅片显示局部血管距离优者可能全局不合理。表明三叉神经痛的MRI-MRA配准应作为局部、血管敏感、对比度敏感、视野感知的可视化任务进行评估,而非通用多模态脑图配准。代码已公开于https://github.com/jhuldr/TN-Reg-Benchmark。

原文摘要 · Abstract (English)

Preoperative evaluation of trigeminal neuralgia (TN) often requires joint interpretation of structural MRI, which depicts the trigeminal nerve and surrounding cisternal anatomy, and time-of-flight MRA, which highlights vascular structures. Although MRI-MRA fusion is clinically attractive for visualizing neurovascular compression, this task is poorly captured by conventional whole-brain registration evaluation because the clinically relevant target is a small trigeminal ROI, vessel annotations are partial and clinically focused, local TOF-MRA contrast is variable, and field-of-view mismatch can limit deformable alignment. We formulate TN MRI-MRA fusion as an ROI-centered neurovascular registration-evaluation problem and construct a benchmark from 149 patients with clinician-annotated bilateral trigeminal ROIs. Six representative registration pipelines were evaluated using local image-based metrics, segmentation-derived vessel-localization metrics, prediction-volume analysis, and contrast- and FOV-stratified comparisons. Conventional evaluation summaries were often misleading: local image similarity, vessel-background separability, and downstream vessel localization did not co-rank methods; one-sided vessel distances were strongly affected by predicted vessel extent under partial annotations; and local MRA contrast determined when vessel-separability metrics were informative. Deformable refinement provided only a small, FOV-dependent benefit over affine alignment, while reader review showed that locally favorable vessel distances could coexist with globally implausible registrations. These findings indicate that TN MRI-MRA registration should be evaluated as a local, vessel-aware, contrast-sensitive, and FOV-aware visualization task rather than as generic multimodal brain registration. Our code is publicly available at https://github.com/jhuldr/TN-Reg-Benchmark.

医学影像配准评估三叉神经痛血管融合

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